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CRTH2, an orphan receptor of T‐helper‐2‐cells, is expressed on basophils and eosinophils and responds to mast cell‐derived factor(s)
Author(s) -
Nagata Kinya,
Hirai Hiroyuki,
Tanaka Kazuya,
Ogawa Kazuyuki,
Aso Takeshi,
Sugamura Kazuo,
Nakamura Masataka,
Takano Shoichi
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01251-x
Subject(s) - mast cell , immune system , immunology , interleukin 33 , receptor , transfection , orphan receptor , antibody , k562 cells , biology , microbiology and biotechnology , cytokine , cell culture , transcription factor , gene , interleukin , leukemia , biochemistry , genetics
We have recently cloned a putative chemoattractant receptor, named CRTH2, which is preferentially expressed on human T‐helper‐ (Th) 2 but not Th1 cells. In this study, we demonstrated that CRTH2 is also highly expressed on peripheral blood basophils and eosinophils. Our search for a CRTH2 ligand identified mast cells as the possible producers of a ligand. When stimulated with an anti‐FcϵR1 antibody, cord blood‐derived mast cells secreted factor(s) that induced Ca 2+ mobilization in CRTH2‐expressing K562 cells but not in mock transfected cells. These findings implied the involvement of CRTH2 in mast cell‐mediated immune responses such as allergic reactions.