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A human homolog of Drosophila warts tumor suppressor, h‐warts, localized to mitotic apparatus and specifically phosphorylated during mitosis
Author(s) -
Nishiyama Yasuyuki,
Hirota Toru,
Morisaki Tetsuro,
Hara Toshihiro,
Marumoto Tomotoshi,
Iida Shin-ichi,
Makino Keishi,
Yamamoto Hideyuki,
Hiraoka Takehisa,
Kitamura Nobuo,
Saya Hideyuki
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01224-7
Subject(s) - mitosis , centrosome , microbiology and biotechnology , aurora b kinase , plk1 , polo like kinase , biology , mitotic exit , midbody , interphase , spindle apparatus , cytokinesis , cell cycle , anaphase , cell division , genetics , gene , cell
We identified a human homolog of Drosophila warts tumor suppressor gene, termed h‐warts , which was mapped at chromosome 6q24‐25.1. The h‐warts protein has a serine/threonine kinase domain and is localized to centrosomes in interphase cells. However, it becomes localized to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, in a highly dynamic manner during mitosis. Furthermore, h‐warts is specifically phosphorylated in cells at mitotic phase, most likely by Cdc2 kinase. These findings suggest that h‐warts functions as a component of the mitotic apparatus and is involved in proper progression of mitosis.