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Activation of channel activity of the NMDA receptor‐PSD‐95 complex by guanylate kinase‐associated protein (GKAP)
Author(s) -
Yamada Yasue,
Chochi Yasuyo,
Ko Ji-Ae,
Sobue Kenji,
Inui Makoto
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01171-0
Subject(s) - guanylate kinase , pdz domain , nmda receptor , postsynaptic density , chemistry , biophysics , microbiology and biotechnology , receptor , biology , biochemistry , membrane protein , membrane
The channel‐associated protein PSD‐95 functionally modulates NMDA receptor channels, interacting with the channels via PDZ domain of PSD‐95. PSD‐95 also interacts with guanylate kinase‐associated protein (GKAP) through the guanylate kinase‐like domain of PSD‐95. Here we report that GKAP markedly potentiates the channel activity of the receptor‐PSD‐95 complex. However, GKAP had no effect on basic properties of the channels nor on PSD‐95‐induced changes in channel properties. Thus, GKAP affects the channel activity of the NMDA receptor via PSD‐95 quantitatively, which may make signal transmission more efficient at postsynaptic sites.