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Difference in induction of uncoupling protein genes in adipose tissues between young and old rats during cold exposure
Author(s) -
Yamashita Hitoshi,
Sato Yuzo,
Mori Nozomu
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01143-6
Subject(s) - uncoupling protein , thermogenin , brown adipose tissue , ucp3 , adipose tissue , white adipose tissue , downregulation and upregulation , prdm16 , endocrinology , medicine , gene expression , biology , gene , messenger rna , genetics
Induction of uncoupling protein (UCP) genes in adipose tissues from young and old rats exposed to cold was compared. UCP1 mRNA expression in brown adipose tissue (BAT) was enhanced in both young and old rats after cold exposure, but the expression was downregulated at 72 h after the exposure only in the young rats. The UCP2 gene was induced notably in BAT of young rats instead of the downregulation of the UCP1 gene, whereas the induction in old rats was almost blunted. The pattern of UCP3 expression was similar to that of UCP1 expression in each group. The effect of cold exposure on the expression of UCP2 genes was also observed in white adipose tissue from the young rats. These results indicate a change in induction of UCP genes in adipose tissues with aging.