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Fibre type specificity of haem oxygenase‐1 induction in rat skeletal muscle
Author(s) -
Vesely M.J.J.,
Sanders R.,
Green C.J.,
Motterlini R.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01129-1
Subject(s) - myoglobin , skeletal muscle , messenger rna , gene expression , soleus muscle , chemistry , heme oxygenase , oxygenase , biochemistry , heme , biology , microbiology and biotechnology , endocrinology , gene , enzyme
The expression of the inducible haem oxygenase (HO‐1) gene was examined in different skeletal muscles. Rats were treated with haemin and a time course of HO‐1 mRNA expression was determined in soleus and extensor digitorum longus (EDL) muscles. Fibre type composition and tissue myoglobin content were also measured. We found that HO‐1 mRNA expression markedly increased in soleus (type I fibres) muscle but was only slightly affected in EDL (type II fibres). HO‐1 expression directly correlated with both percentage of red fibres and tissue myoglobin. These data demonstrate that HO‐1 gene expression follows a fibre type‐specific pattern which might indicate an important role for this protein in the maintenance of skeletal muscle function.