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Immunolocalization of cyclooxygenase‐2 in the macula densa of human elderly
Author(s) -
Nantel François,
Meadows Emily,
Denis Danielle,
Connolly Brett,
Metters Kathleen M.,
Giaid Adel
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)01088-1
Subject(s) - macula densa , cyclooxygenase , afferent arterioles , immunohistochemistry , kidney , cortex (anatomy) , afferent , pathology , medicine , chemistry , endocrinology , anatomy , biology , receptor , renin–angiotensin system , enzyme , neuroscience , angiotensin ii , blood pressure , biochemistry
To gain insight into the role of prostanoids in human kidney function, we examined the distribution of cyclooxygenase (COX) 1 and COX‐2 by immunofluorescence and immunohistochemistry in human kidneys from adults of various age groups. COX‐1 was detected in the collecting ducts, thin loops of Henle and portions of the renal vasculature. COX‐2 was detected in the renal vasculature, medullary interstitial cells, and the macula densa. In addition, COX‐2 immunoreactivity was noted in afferent arteries and the macula densa of the renal cortex and was more evident in the kidneys of older adults.