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The trefoil peptides TFF2 and TFF3 are expressed in rat lymphoid tissues and participate in the immune response
Author(s) -
Cook G.A.,
Familari M.,
Thim L.,
Giraud A.S.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00940-0
Subject(s) - mucin , immune system , trefoil , biology , gastrointestinal tract , immunology , microbiology and biotechnology , messenger rna , spleen , glycoprotein , inflammation , gene , biochemistry , agronomy
Members of the trefoil factor (TFF) family are mucin‐associated polypeptides that are expressed along the entire length of the gastrointestinal tract. TFFs have been proposed to play a role in mucosal defence through both protective and reparative mechanisms. The potential relationship between TFFs and mucins in non‐gut glycoprotein‐secreting epithelia has not been fully explored. In the present study we identified TFF2 and TFF3 mRNA and peptide in rat lymphoid tissues, demonstrated that TFF peptide expression in rat spleen increased 1.5‐ to 3‐fold following experimental induction of the immune response, and showed that hTFF2 and hTFF3 (1–5 mg/ml) stimulated migration of human monocytes. Our data suggest that TFFs may in part be involved in the repair of injury through the modulation of the inflammatory response.