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Endothelin‐1 induces expression of fetal genes through the interleukin‐6 family of cytokines in cardiac myocytes
Author(s) -
Saito Shuichi,
Aikawa Ryuichi,
Shiojima Ichiro,
Nagai Ryozo,
Yazaki Yoshio,
Komuro Issei
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00936-9
Subject(s) - glycoprotein 130 , medicine , endocrinology , leukemia inhibitory factor , atrial natriuretic peptide , myocyte , endothelin 1 , biology , gene expression , fetus , tyrosine kinase , leukemia inhibitory factor receptor , gene , microbiology and biotechnology , chemistry , receptor , interleukin 6 , cytokine , genetics , pregnancy
We here examined the role of the interleukin‐6 (IL‐6) family of cytokines in endothelin‐1 (ET‐1)‐induced hypertrophic responses using cultured cardiac myocytes of neonatal rats. ET‐1 induced expression of IL‐6 and leukemia inhibitory factor (LIF) genes. ET‐1‐induced LIF gene expression was abolished by inhibition of protein kinase C activity. ET‐1 activated the promoter of atrial natriuretic peptide and β‐type myosin heavy chain genes through the tyrosine kinase pathway and IL‐6 receptor gp130. These results suggest that the IL‐6 family of cytokines mediates ET‐1‐induced expression of some fetal genes in cardiac myocytes.