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Identification of three novel members of the calcium‐dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea 1
Author(s) -
Agnel Magali,
Vermat Thierry,
Culouscou Jean-Michel
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00891-1
Subject(s) - subfamily , homology (biology) , biology , gene , gene family , chloride channel , calmodulin , microbiology and biotechnology , genetics , gene expression , biochemistry , enzyme
Three novel human sequences showing striking homology to the recently described bovine Ca 2+ /calmodulin kinase II‐dependent epithelial chloride channel bCaCC have been identified in an expressed sequence tags database. Full‐length clones were isolated using a 5′ RACE approach. The encoded predicted proteins display 65% overall homology to bCaCC. Tissue expression patterns of the corresponding genes, designated as hCaCC‐1, ‐2 and ‐3, appear to be highly restricted, with the first two genes primarily expressed in the digestive tract. Another original feature as compared to the CaCC family members is the fact that hCaCC‐2 also shows expression in the brain. Taken together these findings demonstrate the existence of several CaCC‐like genes in humans, some of which display distinct tissue specificity patterns within the CaCC subfamily of chloride channels.