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Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells
Author(s) -
Slominski Andrzej,
Gomez-Sanchez Celso E.,
Foecking Mark F.,
Wortsman Jacobo
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00889-3
Subject(s) - corticosterone , endocrinology , medicine , metabolism , melanoma , chemistry , biology , hormone , cancer research
We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12‐fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11‐deoxycorticosterone, corticosterone, and 18‐hydroxydeoxycorticosterone.