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Novel anti‐inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase‐2 in mouse peritoneal macrophages
Author(s) -
Herencia Felipe,
Ferrándiz M.Luisa,
Ubeda Amalia,
Guillén Isabel,
Dominguez José N.,
Charris Jaime E.,
Lobo Gricela M.,
Alcaraz M.José
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00707-3
Subject(s) - chalcone , nitric oxide synthase , nitric oxide , cyclooxygenase , zymosan , chemistry , lipopolysaccharide , enzyme , biochemistry , atp synthase , pharmacology , inhibitory postsynaptic potential , biology , in vitro , immunology , stereochemistry , endocrinology , organic chemistry
In a previous work, we tested a series of chalcone derivatives as possible anti‐inflammatory compounds. We now investigate the effects of three of those compounds, CH1, CH8 and CH12, on nitric oxide and prostanoid generation in mouse peritoneal macrophages stimulated with lipopolysaccharide and in the mouse air pouch injected with zymosan, where they showed a dose‐dependent inhibition with inhibitory concentration 50% values in the μM range. This effect was not the consequence of a direct inhibitory action on enzyme activities. Our results demonstrated that chalcone derivatives inhibited de novo inducible nitric oxide synthase and cyclooxygenase‐2 synthesis, being a novel therapeutic approach for inflammatory diseases.