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Dual effects of suppressor of cytokine signaling (SOCS‐2) on growth hormone signal transduction
Author(s) -
Favre Hélène,
Benhamou Aurélie,
Finidori Joelle,
Kelly Paul A.,
Edery Marc
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00681-x
Subject(s) - socs3 , stat5 , suppressor of cytokine signaling 1 , signal transduction , suppressor of cytokine signalling , cytokine , socs2 , transcription factor , microbiology and biotechnology , biology , chemistry , medicine , endocrinology , suppressor , immunology , gene , stat3 , biochemistry
A family of suppressors of cytokine signaling (SOCS) has recently been identified of which two members have been shown to block growth hormone (GH) signaling. Dose‐response experiments were conducted in 293 cells and SOCS‐1 and SOCS‐3 were shown to inhibit the transcriptional activation of a GH‐responsive element and suppressed Jak2 tyrosine kinase activity. SOCS‐2 had two opposite effects: at low concentrations it inhibited GH‐induced STAT5‐dependent gene transcription, but restoration of GH signaling was observed at higher concentrations. In cotransfection studies, SOCS‐2 was able to block the inhibitory effect of SOCS‐1 but not that of SOCS‐3 on GH signaling. These findings suggest that a major function for SOCS‐2 is to restore the sensitivity to GH by overcoming the initial inhibitory effects of other endogenous SOCS molecules.