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Lipid signaling in CD95‐mediated apoptosis
Author(s) -
Malisan Florence,
Testi Roberto
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00543-8
Subject(s) - ceramide , sphingomyelin , microbiology and biotechnology , fas receptor , apoptosis , lipid signaling , glycosphingolipid , ganglioside , chemistry , sphingolipid , signal transduction , biochemistry , receptor , biology , programmed cell death , cholesterol
Ceramides play an important role mediating different cell responses such as proliferation, differentiation, growth arrest and apoptosis. They are released upon sphingomyelin hydrolysis which occurs after triggering of a number of cell surface receptors including CD95. Ceramide generation also regulates glycosphingolipid and ganglioside metabolism. In particular, ganglioside GD3 biosynthesis represents an important event for the progression of apoptotic signals generated by CD95 and mediated by ceramide in hematopoietic cells.