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Protein kinases in control of the centrosome cycle
Author(s) -
Mayor Thibault,
Meraldi Patrick,
Stierhof York-Dieter,
Nigg Erich A.,
Fry Andrew M.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00534-7
Subject(s) - centrosome , centrosome cycle , microbiology and biotechnology , integrin linked kinase , polo like kinase , mitosis , spindle pole body , biology , cell cycle , plk1 , spindle apparatus , microtubule organizing center , kinase , multipolar spindles , interphase , cell division , chemistry , protein kinase a , cyclin dependent kinase 2 , biochemistry , cell
The centrosome is the major microtubule nucleating center of the animal cell and forms the two poles of the mitotic spindle upon which chromosomes are segregated. During the cell division cycle, the centrosome undergoes a series of major structural and functional transitions that are essential for both interphase centrosome function and mitotic spindle formation. The localization of an increasing number of protein kinases to the centrosome has revealed the importance of protein phosphorylation in controlling many of these transitions. Here, we focus on two protein kinases, the polo‐like kinase 1 and the NIMA‐related kinase 2, for which recent data indicate key roles during the centrosome cycle.