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Nuclear transport and transcriptional regulation
Author(s) -
Turpin Pierre,
Ossareh-Nazari Batool,
Dargemont Catherine
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00533-5
Subject(s) - nuclear transport , nucleus , microbiology and biotechnology , nuclear pore , nuclear export signal , cell nucleus , regulation of gene expression , transcriptional regulation , gene expression , nuclear receptor , nuclear localization sequence , gene , biology , chemistry , transcription factor , genetics
Studies over the past 10 years have provided major insights into the molecular mechanisms responsible for active transport of macromolecules in and out of the nucleus. Nucleocytoplasmic transport pathways correspond to active and signal‐mediated processes that involve substrates, adaptors and receptors. Regulation of both nuclear import and nuclear export is mainly exerted at the level of transport complex formation and has emerged as one of the most efficient mechanisms to adapt gene expression to the cell environment by restricting the access of transcriptional regulators to their target genes.