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Mitochondrial assembly in yeast
Author(s) -
Grivell Les A,
Artal-Sanz Marta,
Hakkaart Gertjan,
de Jong Liesbeth,
Nijtmans Leo G.J,
van Oosterum Katinka,
Siep Michel,
van der Spek Hans
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00532-3
Subject(s) - yeast , saccharomyces cerevisiae , mitochondrion , organelle , biology , translation (biology) , organism , computational biology , electron transport chain , microbiology and biotechnology , biochemistry , genetics , gene , messenger rna
The yeast Saccharomyces cerevisiae is likely to be the first organism for which a complete inventory of mitochondrial proteins and their functions can be drawn up. A survey of the 340 or so proteins currently known to be localised in yeast mitochondria reveals the considerable investment required to maintain the organelle's own genetic system, which itself contributes seven key components of the electron transport chain. Translation and respiratory complex assembly are particularly expensive processes, together requiring around 150 of the proteins so far known. Recent developments in both areas are reviewed and approaches to the identification of novel mitochondrial proteins are discussed.