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Cytoskeleton cross‐talk during cell motility
Author(s) -
Small J.Victor,
Kaverina Irina,
Krylyshkina Olga,
Rottner Klemens
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00530-x
Subject(s) - motility , cytoskeleton , microbiology and biotechnology , chemistry , cell , biology , biochemistry
Cell crawling entails the co‐ordinated creation and turnover of substrate contact sites that interface with the actin cytoskeleton. The initiation and maturation of contact sites involves signalling via the Rho family of small G proteins, whereas their turnover is under the additional influence of the microtubule cytoskeleton. By exerting relaxing effects on substrate contact assemblies in a site‐ and dose‐specific manner, microtubules can promote both protrusion at the front and retraction at the rear, and thereby control cell polarity.