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Effects of frontotemporal dementia FTDP‐17 mutations on heparin‐induced assembly of tau filaments
Author(s) -
Goedert Michel,
Jakes Ross,
Crowther R.Anthony
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00508-6
Subject(s) - missense mutation , frontotemporal dementia , tau protein , parkinsonism , genetics , mutation , biology , chemistry , gene , dementia , medicine , alzheimer's disease , pathology , disease
Missense mutations and intronic mutations in the gene for microtubule‐associated protein tau cause frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP‐17). Most missense mutations have as likely primary effect a reduced ability of tau to interact with microtubules. We report here an additional effect of several missense mutations, namely the stimulation of heparin‐induced filament assembly of recombinant tau, despite the absence of any change in structure indicated by circular dichroism. These findings indicate that missense mutations in tau lead to frontotemporal dementia through potentially multiple mechanisms.