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Mutation patterns for two flaviviruses: hepatitis C virus and GB virus C/hepatitis G virus
Author(s) -
Mizokami Masashi,
Imanishi Tadashi,
Ikeo Kazuho,
Suzuki Yoshiyuki,
Orito Etsuro,
Kumada Takashi,
Ueda Ryuzo,
Iino Shiro,
Nakano Tatsunori
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00507-4
Subject(s) - virology , pseudogene , virus , hepatitis c virus , biology , mutation , gb virus c , flaviviridae , hepatitis b virus , gene , genome , genetics
We studied the mutation patterns of hepatitis C virus (HCV) and GB virus C/hepatitis G virus (HGV). Although the mutation patterns of the two viruses were similar to each other, they were quite different from that of HIV. In particular, the similarity of the patterns between HCV or HGV and human nuclear pseudogenes was statistically significant whereas there was no similarity between HIV and human nuclear pseudogenes. This finding suggests that the mutation patterns of HCV and HGV are similar to the patterns of spontaneous substitution mutations of human genes, implying that nucleotide analogues which are effective against HCV and HGV may have a side effect on the normal cells of humans.