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Absorption and metabolism of cyanidin 3‐ O ‐β‐ D ‐glucoside in rats
Author(s) -
Tsuda Takanori,
Horio Fumihiko,
Osawa Toshihiko
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00407-x
Subject(s) - cyanidin , antioxidant , anthocyanin , chemistry , metabolism , protocatechuic acid , in vivo , biochemistry , bioavailability , kidney , endocrinology , food science , pharmacology , biology , microbiology and biotechnology
We have clarified for the first time how cyanidin 3‐ O ‐β‐ D ‐glucoside (C3G), which is a potent antioxidant anthocyanin, is absorbed and metabolized in vivo. Rats were orally administered C3G (0.9 mmol/kg body weight), and C3G rapidly appeared in the plasma. However, the aglycon of C3G (cyanidin; Cy) was not detected, although it was present in the jejunum. Protocatechuic acid (PC), which may be produced by degradation of Cy, was present in the plasma and the concentration was 8‐fold higher than that of C3G. These results suggest that plasma PC and C3G may contribute to the antioxidant activity of the plasma. In the liver and kidney, C3G was metabolized to methylated C3G (methyl‐C3G), suggesting that C3G and/or methyl‐C3G act as antioxidants in the tissues.