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Angiopoietin‐3, a novel member of the angiopoietin family
Author(s) -
Nishimura Motoi,
Miki Takashi,
Yashima Rei,
Yokoi Norihide,
Yano Hideki,
Sato Yasufumi,
Seino Susumu
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00381-6
Subject(s) - umbilical vein , complementary dna , angiopoietin , messenger rna , cdna library , angiopoietin 2 , microbiology and biotechnology , biology , gene , vascular endothelial growth factor , biochemistry , cancer research , in vitro , vegf receptors
A cDNA clone encoding angiopoietin‐3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin‐1 and human angiopoietin‐2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2.