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Angiopoietin‐1 is an apoptosis survival factor for endothelial cells
Author(s) -
Kwak Hee Jin,
So June-No,
Lee Song Jae,
Kim Injune,
Koh Gou Young
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00378-6
Subject(s) - apoptosis , umbilical vein , angiopoietin , chemistry , microbiology and biotechnology , vascular endothelial growth factor , growth factor , function (biology) , biology , cancer research , in vitro , biochemistry , vegf receptors , receptor
We examined the effect of angiopoietin‐1 (Ang1) on apoptosis in human umbilical vein endothelial cells (HUVECs). Ang1 (5–1000 ng/ml) dose‐dependently inhibited apoptosis under a serum‐deprived state. A significant apoptotic inhibition occurred with as low as 50 ng/ml. Two hundred ng/ml of Ang1 inhibited to approximately 50% of the control apoptotic rates for 96 h. Furthermore, an augmented antiapoptotic effect of Ang1 by the addition of 20 ng/ml vascular endothelial growth factor was observed. This Ang1‐induced strong antiapoptotic effect in endothelial cells is a novel and intriguing finding and could be an additional description of Ang1‐induced direct biological function.