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Second form of gonadotropin‐releasing hormone in mouse: immunocytochemistry reveals hippocampal and periventricular distribution
Author(s) -
Gestrin Emily D,
White Richard B,
Fernald Russell D
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00361-0
Subject(s) - immunocytochemistry , gonadotropin releasing hormone , hippocampal formation , endocrinology , medicine , midbrain , biology , vertebrate , hippocampus , hormone , central nervous system , luteinizing hormone , biochemistry , gene
Hypothalamic GnRH (GnRH‐I) is known and named for its role in regulating reproductive function in vertebrates by controlling release of gonadotropins from the pituitary. However, another form of GnRH of unknown function (pGlu‐His‐Trp‐Ser‐His‐Gly‐Trp‐Tyr‐Pro‐Gly; GnRH‐II) is expressed in the mesencephalon of all vertebrate classes except jawless fish. Here we show with immunocytochemical staining that the GnRH‐II peptide is localized to the mouse midbrain as in other vertebrates, as well as in cells surrounding the ventricles and in cells adjacent to the hippocampus. Staining of adjacent sections using GnRH‐I antibody revealed that the distribution of GnRH‐I does not overlap with that of GnRH‐II.