Premium
Quality control: from molecules to organelles
Author(s) -
Luzikov Valentin N
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00344-0
Subject(s) - organelle , folding (dsp implementation) , proteases , function (biology) , control (management) , mechanism (biology) , cytosol , computer science , correctness , chemistry , microbiology and biotechnology , computational biology , biology , biochemistry , enzyme , physics , engineering , artificial intelligence , algorithm , quantum mechanics , electrical engineering
There is a vast body of literature on the quality control of protein folding and assembly into multisubunit complexes. Such control takes place everywhere in the cell. The correcting mechanisms involve cytosolic and organellar proteases; the result of such control is individual molecules with proper structure and individual complexes both with proper stoichiometry and proper structure. Obviously, the formation of organelles as such requires some additional criteria of correctness and some new mechanisms of their implementation. It is proposed in this article that the ability to carry out an integral (key) function may serve as a criterion of correct organelle assembly and that autophagy can be accepted as a mechanism eliminating the assembly mistakes.