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Cell surface expression of the metabotropic glutamate receptor type 1α is regulated by the C‐terminal tail
Author(s) -
Ciruela F.,
Soloviev M.M.,
McIlhinney R.A.J.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00341-5
Subject(s) - metabotropic glutamate receptor , biotinylation , metabotropic glutamate receptor 6 , metabotropic glutamate receptor 1 , metabotropic glutamate receptor 2 , metabotropic glutamate receptor 7 , metabotropic glutamate receptor 5 , metabotropic glutamate receptor 4 , metabotropic receptor , receptor , chemistry , microbiology and biotechnology , cell , 5 ht5a receptor , agonist , biochemistry , biology
The cell surface expression of metabotropic glutamate receptor type 1 splice variants has been studied using cell surface biotinylation. Co‐expression of the last 86 residues of the C‐terminal tail of mGluR1α (F2‐protein) with mGluR1α caused a significant reduction of the amount of the cell surface receptor when compared to that in cells transfected with mGlur1α alone, and this was accompanied by a reduction in the production of inositol following agonist stimulation of the cells. In contrast, cell surface expression of mGluR1β was unaltered by co‐expression with the F2‐protein. These results suggest that the C‐terminal tail of mGluR1α regulates cell surface expression of the receptor.