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A comparative study of the calcium system in memory T cells and naive T cells
Author(s) -
Sigova Alla,
Dedkova Elena,
Zinchenko Valery,
Litvinov Ivan
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00260-4
Subject(s) - ionomycin , thapsigargin , chemistry , calcium , immunological memory , thimerosal , intracellular , microbiology and biotechnology , immunology , biology , immune system , medicine , immunity , organic chemistry , dermatology
The comparative analysis of responses of memory and naive T lymphocytes to Ca 2+ ‐mobilizing agents, namely Con A, thimerosal, thapsigargin and ionomycin, was carried out. The effect of these agents on both types of T cells differed qualitatively and quantitatively. The lack of intracellular Ca 2+ stores in memory T cells was shown. Ca 2+ ‐mobilizing agents did not induce influx of Ca 2+ in memory T cells from outside and this was the reason for their stability to Ca 2+ ionophores. It was also shown that memory T cells were resistant to the ‘Ca 2+ paradox’.