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Iron overload upregulates haem oxygenase 1 in the lung more rapidly than in other tissues
Author(s) -
Anning Peter B.,
Chen Yan,
Lamb Nicholas J.,
Mumby Sharon,
Quinlan Gregory J.,
Evans Timothy W.,
Gutteridge John M.C.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00250-1
Subject(s) - heme oxygenase , oxygenase , downregulation and upregulation , oxidative stress , chemistry , lung , heme , biochemistry , biology , medicine , enzyme , gene
Haem oxygenase‐1 is upregulated by numerous insults, including oxidative stress, and under such circumstances it is considered to be a protective stratagem. We have measured the haem oxygenase‐1 expression in heart, lung and liver tissues of control and iron‐overloaded rats. Lung tissue from iron‐overloaded rats displayed a significant increase in the haem oxygenase‐1 protein but no changes in haem oxygenase‐1 mRNA. Conversely, heart tissue showed a significant increase in haem oxygenase‐1 mRNA but no changes in haem oxygenase‐1 protein. We conclude that during oxidative stress caused by iron overload, lung tissue responds with a rapid upregulation of haem oxygenase‐1 levels.