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Mapping of the MYCL2 processed gene to Xq22‐23 and identification of an additional L MYC‐related sequence in Xq27.2
Author(s) -
Redolfi E,
Pizzuti A,
Di Bacco A,
Susani L,
Labella T,
Affer M,
Montagna C,
Reinbold R,
Mumm S,
Vezzoni P,
Zucchi I
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00243-4
Subject(s) - exon , genetics , homology (biology) , gene , biology , x chromosome , chromosome , sequence analysis , sequence (biology) , sequence tagged site , dna sequencing , genomic dna , microbiology and biotechnology , gene mapping
We report here the identification of a human genomic sequence from the q27.2 region of the X chromosome which shows a high homology to the L‐MYC proto‐oncogene. This sequence is not the MYCL2 homology, previously mapped to the long arm of the X chromosome at q22‐qter by Morton et al., as we located the MYCL2‐processed gene in Xq22‐23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome. Based on computer analysis, the MYC‐like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, between the DXS312 and DXS292 loci.