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A second mechanism of respiratory control
Author(s) -
Kadenbach Bernhard,
Arnold Susanne
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00229-x
Subject(s) - electron transport chain , respiration , cytochrome c oxidase , chemiosmosis , atp synthase , mitochondrion , chloroplast , photosynthesis , biophysics , mechanism (biology) , cellular respiration , chemistry , biochemistry , phosphorylation , protein subunit , biology , enzyme , botany , physics , quantum mechanics , gene
According to the chemosmotic hypothesis, ATP is synthesized in mitochondria, bacteria and chloroplasts via the proton motive force Δ p , the energy‐rich intermediate of electron transport and photosynthetic phosphorylation. The general applicability of the chemosmotic hypothesis, however, was disputed until present. In particular the relationship between the rate of respiration and Δ p in mitochondria was found variable, depending on the experimental conditions. Recently, a new mechanism of respiratory control was found, based on binding of ATP or ADP to subunit IV of cytochrome c oxidase, which is independent of Δ p and could explain many previous results contradicting the chemosmotic hypothesis.