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Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers
Author(s) -
Melik-Nubarov N.S.,
Pomaz O.O.,
Dorodnych T.Yu.,
Badun G.A.,
Ksenofontov A.L.,
Schemchukova O.B.,
Arzhakov S.A.
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00208-2
Subject(s) - microviscosity , poloxamer , propylene oxide , ethylene oxide , membrane , copolymer , biophysics , chemistry , polymer , biochemistry , organic chemistry , biology
Ethylene oxide and propylene oxide block copolymers (pluronics) are widely known as agents that promote drug penetration across biological barriers. We have studied the interaction of normal and malignant blood cells with pluronics L61 and P85 that have different hydrophobicity. SP2/0 myeloma cells accumulated pluronics while normal cells adsorb most of the polymer on the surface. Interaction of pluronics with cells resulted in drastic changes of membrane microviscosity. Tumor cell membrane microviscosity decreased after pluronics adsorption, in contrast to normal cells, whose membrane microviscosity was enhanced. We suppose that sensitivity of tumor cell membrane microviscosity to the pluronics action correlates with its permeability for molecular substances.