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Evidence for an ancient chromosomal duplication in Arabidopsis thaliana by sequencing and analyzing a 400‐kb contig at the APETALA2 locus on chromosome 4 1
Author(s) -
Terryn Nancy,
Heijnen Leo,
De Keyser Annick,
Van Asseldonck Martien,
De Clercq Rebecca,
Verbakel Henk,
Gielen Jan,
Zabeau Marc,
Villarroel Raimundo,
Jesse Taco,
Neyt Pia,
Hogers René,
Van Den Daele Hilde,
Ardiles Wilson,
Schueller Christine,
Mayer Klaus,
Déhais Patrice,
Rombauts Stephane,
Van Montagu Marc,
Rouzé Pierre,
Vos Pieter
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00097-6
Subject(s) - contig , genetics , biology , locus (genetics) , gene , gene duplication , arabidopsis , homology (biology) , chromosome , coding region , dna sequencing , genome , mutant
As part of the European Scientists Sequencing Arabidopsis program, a contiguous region (396 607 bp) located on chromosome 4 around the APETALA2 gene was sequenced. Analysis of the sequence and comparison to public databases predicts 103 genes in this area, which represents a gene density of one gene per 3.85 kb. Almost half of the genes show no significant homology to known database entries. In addition, the first 45 kb of the contig, which covers 11 genes, is similar to a region on chromosome 2, as far as coding sequences are concerned. This observation indicates that ancient duplications of large pieces of DNA have occurred in Arabidopsis .