Premium
Submitochondrial and subcellular distributions of the carnitine‐acylcarnitine carrier
Author(s) -
Fraser Fiona,
Zammit Victor A
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00095-2
Subject(s) - submitochondrial particle , peroxisome , biochemistry , carnitine , mitochondrion , translocase , subcellular localization , chemistry , microsome , cytoplasm , biology , enzyme , chromosomal translocation , receptor , gene
The submitochondrial and subcellular distributions of the carnitine‐acylcarnitine translocase (CAC) have been studied. CAC is enriched to a much lesser extent than the carnitine palmitoyltransferases within the contact sites of mitochondria. A high‐abundance protein of identical molecular size as the mitochondrial CAC that is immunoreactive with an anti‐peptide antibody raised against a linear epitope of mitochondrial CAC is present in peroxisomes but not in microsomes. This suggests that CAC is targeted to at least two different locations within the liver cell and that acylcarnitine transport into peroxisomes is CAC mediated.