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Expression of plasminogen‐related gene B varies among normal tissues and increases in cancer tissues
Author(s) -
Tateno Tadashi,
Ichinose Akitada
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00093-9
Subject(s) - biology , gene , microbiology and biotechnology , gene expression , cancer , messenger rna , kidney , transcription (linguistics) , genetics , philosophy , linguistics
We previously found that the promoter activity of plasminogen (PLG)‐related gene B (PRGB) was 5‐fold that of PLG. We have since examined the transcript levels of PRGB among various normal human tissues, and compared these findings with those of PLG. Reverse transcription‐PCR analysis revealed that the PRGB expression varied widely among different tissues, while PLG was expressed only in the liver and kidney. RNA samples obtained from cultured cell lines also demonstrated differing PRGB expression. Furthermore, increased PRGB expression was observed in several fresh samples of cancer tissue obtained from cancer patients when compared with surrounding normal tissues.