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Expression of uncoupling protein‐3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle
Author(s) -
Lanni A,
Beneduce L,
Lombardi A,
Moreno M,
Boss O,
Muzzin P,
Giacobino J.P,
Goglia F
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00061-7
Subject(s) - ucp3 , uncoupling protein , euthyroid , skeletal muscle , medicine , endocrinology , respiration , triiodothyronine , chemistry , biology , basal metabolic rate , thyroid , anatomy , brown adipose tissue , obesity
We sought a correlation between rat skeletal muscle triiodothyronine (T3)‐mediated regulation of uncoupling protein‐3 (UCP3) expression and mitochondrial activity. UCP3 mRNA expression increased strongly during the hypothyroid‐hyperthyroid transition. The rank order of mitochondrial State 3 and State 4 respiration rates was hypothyroid