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Three receptor genes for plasminogen related growth factors in the genome of the puffer fish Fugu rubripes 1
Author(s) -
Cottage Amanda,
Clark Melody,
Hawker Kelvin,
Umrania Yagnesh,
Wheller Denis,
Bishop Martin,
Elgar Greg
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(99)00011-3
Subject(s) - fugu , fish <actinopterygii> , gene , biology , genome , genetics , fishery
Plasminogen related growth factors (PRGFs) and their receptors play major roles in embryogenesis, tissue regeneration and neoplasia. In order to investigate the complexity and evolution of the PRGF receptor family we have cloned and sequenced three receptors for PRGFs in the teleost fish Fugu rubripes , a model vertebrate with a compact genome. One of the receptor genes isolated encodes the orthologue of mammalian MET, whilst the other two may represent Fugu rubripes orthologues of RON and SEA. This is the first time three PRGF receptors have been identified in a single species.