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Isolation of p ‐hydroxycinnamaldehyde as an antibacterial substance from the saw fly, Acantholyda parki S
Author(s) -
Leem Jae Yoon,
Jeong Im Ju,
Park Kyu Tek,
Park Ho Yong
Publication year - 1999
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01614-7
Subject(s) - antibacterial activity , candida albicans , bacteria , isolation (microbiology) , chemistry , antifungal , insect , microbiology and biotechnology , antimicrobial , gram , stereochemistry , biology , organic chemistry , botany , genetics
We purified an antibacterial substance from larvae of the saw fly, Acantholyda parki S., and identified its molecular structure as p ‐hydroxycinnamaldehyde. We then synthesized it by reduction of p ‐hydroxycinnamic acid. The antibacterial activity of the synthetic p ‐hydroxycinnamaldehyde was equal to that of the authentic substance. This molecule was found to have a broad antibacterial spectrum against not only Gram‐negative, but also Gram‐positive bacteria. Furthermore, it showed antifungal activity against Candida albicans . We suggest that this substance may play a role in the defense system of this insect. This is the first report of p ‐hydroxycinnamaldehyde of animal origin.