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9‐ cis Retinoic acid induces the expression of the uncoupling protein‐2 gene in brown adipocytes
Author(s) -
Carmona M.C,
Valmaseda A,
Iglesias R,
Mampel T,
Viñas O,
Giralt M,
Villarroya F
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01598-1
Subject(s) - retinoic acid , retinoid x receptor , retinoid , retinoic acid receptor , retinoic acid receptor gamma , uncoupling protein , retinoid x receptor gamma , retinoic acid inducible orphan g protein coupled receptor , messenger rna , receptor , gene expression , retinoic acid receptor beta , retinoid x receptor alpha , biology , retinoic acid receptor alpha , chemistry , endocrinology , microbiology and biotechnology , biochemistry , gene , nuclear receptor , brown adipose tissue , adipose tissue , transcription factor
The expression of uncoupling protein‐2 (UCP2) mRNA is up‐regulated during the differentiation of brown adipocytes in primary culture. When differentiation of brown adipocytes is impaired, UCP2 mRNA expression is down‐regulated. 9‐ cis Retinoic acid causes a dose‐dependent induction of UCP2 mRNA levels in brown adipocytes, whereas all‐ trans retinoic acid has no effect. Specific agonists of retinoid X receptors (RXR) induce UCP2 mRNA expression, whereas specific activators of retinoic acid receptors do not. 9‐ cis Retinoic acid, acting through RXR receptors, is identified as a major regulator of the expression of the UCP2 gene in the brown fat cell.