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Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain
Author(s) -
Sun Lixin,
Margolis Frank L.,
Shipley Michael T.,
Lidow Michael S.
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01590-7
Subject(s) - nmda receptor , hippocampus , protein subunit , neuroscience , entorhinal cortex , messenger rna , biology , thalamus , receptor , biochemistry , gene
A longer variant of rat mRNA encoding the NR3 subunit of the NMDA receptor has been identified. It contains a 60‐bp insertion at the nucleotide position 3007 in the intracellular domain of the C‐terminal of the previously cloned variant. Therefore, the NR3 mRNA exists in at least two variants – with the insert (NR3‐long; NR3‐l) and without the insert (NR3‐short; NR3‐s). The NR3‐l variant is expressed throughout the adult rat brain. Moreover, this variant predominates in the occipital and entorhinal cortices, thalamus and cerebellum. Analysis of NR3‐l development indicates that it is regulated in a region‐specific manner.