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EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran‐binding domains of the RanBP1 family
Author(s) -
Callebaut Isabelle,
Cossart Pascale,
Dehoux Pierre
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01541-5
Subject(s) - egf like domain , ran , hamp domain , biology , homology (biology) , microbiology and biotechnology , cytoskeleton , computational biology , protein family , protein domain , binding domain , genetics , gene , binding site , cell
The two cytoskeletal proteins VASP and WASP and the protein Homer share a conserved domain, currently designated the WH1 domain ( ASP omology domain ) or EVH1 domain ( NA/ ASP omology domain ), which could play an important role in various cellular events such as transport, folding of proteins, and signal transduction. We report here additional occurrences of this domain in Ran‐binding proteins of the RanBP1 family and various others proteins, or putative proteins of eukaryotic organisms, suggesting that the EVH1/WH1 domain may be more widely used than originally thought.