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Velcro in the nuclear envelope: LBR and LAPs
Author(s) -
Chu Angel,
Rassadi Roozbeh,
Stochaj Ursula
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01534-8
Subject(s) - nuclear lamina , lamin , inner membrane , chromatin , microbiology and biotechnology , mitosis , nuclear pore , interphase , biology , nuclear membrane , nuclear protein , nuclear transport , cell nucleus , nucleus , genetics , gene , transcription factor , mitochondrion
The nuclear envelope is crucial for the functional organization of the nucleus. Lamin B receptor (LBR) and several lamina‐associated proteins (LAPs), residing in the inner membrane, provide attachment sites for chromatin and the nuclear lamina. LAPs and LAP‐related proteins are members of a growing family of proteins, whose genes are expressed in a tissue and development specific manner, opening the opportunity for a complex regulation of membrane‐chromatin and membrane‐lamina interactions. Post‐translational modifications of LBR and LAPs are likely to modulate their binding to lamins and chromatin, interactions that need to be dynamic to accommodate nuclear growth in interphase and nuclear envelope disassembly in mitosis. Accumulation of proteins in the inner nuclear membrane is believed to depend on their retention mediated by the interaction with nuclear components such as chromatin and lamins.