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A novel human RasGAP‐like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25
Author(s) -
Noto Satoshi,
Maeda Tatsuya,
Hattori Seisuke,
Inazawa Johji,
Imamura Masahiro,
Asaka Masahiro,
Hatakeyama Masanori
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01530-0
Subject(s) - complementary dna , biology , locus (genetics) , gene product , gene , genetics , homology (biology) , gene mapping , microbiology and biotechnology , gene expression , chromosome
We report the molecular cloning of a human cDNA that encodes a molecule having striking homology with Ras‐specific GTPase‐activating proteins (RasGAPs). Among previously described RasGAPs, the cDNA product is most closely related to Caenorhabditis elegans GAP‐2, including a predicted coiled‐coil structure near the carboxyl terminus. Expression of the cDNA in Saccharomyces cerevisiae defective in one of two RasGAPs, Ira2, complemented loss of the Ira2 function, indicating that the cDNA product functions as a RasGAP. The RasGAP‐like gene is located on the human chromosome 1q25, the locus that appears to contain a hereditary prostate cancer susceptible gene, HPC1 .