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Specific detections of the early process of the glycation reaction by fructose and glucose in diabetic rat lens
Author(s) -
Kawasaki Yoshimi,
Fujii Junichi,
Miyazawa Nobuko,
Hoshi Ayumu,
Okado Ayako,
Tano Yasuo,
Taniguchi Naoyuki
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01529-4
Subject(s) - glycation , fructose , sorbitol , diabetes mellitus , chemistry , medicine , polyol pathway , endocrinology , lysine , biochemistry , aldose reductase , amino acid
The glycation reaction by fructose, as well as that by glucose, in control and diabetic rat lens was analyzed by using antibodies which specifically recognize adducts of lysine with fructose and with glucose. Levels of fructose adducts in diabetic rat lens were 2.5 times that of the control, and correlated with sorbitol levels. This was mainly due to enhanced glycation of β‐ and γ‐crystallins by fructose under diabetic conditions. These data suggest that glycation by fructose may also play a role in cataract formation under conditions of diabetes and aging.