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Lysophosphatidylcholine generates superoxide anions through activation of phosphatidylinositol 3‐kinase in human neutrophils
Author(s) -
Nishioka Hiroaki,
Horiuchi Hisanori,
Arai Hidenori,
Kita Toru
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01526-9
Subject(s) - lysophosphatidylcholine , phosphatidylinositol , superoxide , protein kinase c , kinase , chemistry , microbiology and biotechnology , biochemistry , enzyme , biology , phospholipid , phosphatidylcholine , membrane
Lysophosphatidylcholine (LPC) accumulates in inflammatory tissues, where neutrophils are recruited to generate superoxide anions (O ⋅− 2 ). Here, we show that LPC stimulates O ⋅− 2 generation in human neutrophils and that the activity is inhibited with phosphatidylinositol 3‐kinase (PI3 kinase) inhibitors, but not with protein kinase C (PKC) inhibitors. Furthermore, we demonstrate that LPC activates PI3 kinase in neutrophils. Thus, LPC might contribute to host defense by generating O ⋅− 2 in neutrophils through PI3 kinase activation, but not through PKC activation.