Premium
Linker histones: paradigm lost but questions remain
Author(s) -
Belikov Sergey,
Karpov Vadim
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01512-9
Subject(s) - nucleosome , linker , histone , chromatosome , linker dna , chromatin , chemistry , biophysics , computational biology , histone code , domain (mathematical analysis) , microbiology and biotechnology , genetics , biology , biochemistry , dna , computer science , mathematics , operating system , mathematical analysis
Linker histones (LH) represent a diverse family of proteins that bind to nucleosomes and bring them together to form a 30‐nm chromatin fiber. Although the structure of the globular domain of linker histones H1 and H5 has been solved, the details of its interaction with the nucleosome are not understood in full. Recent data on the location of LH in nucleosome are discussed here.