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In the rat, tumor necrosis factor α administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine‐induced thermogenesis?
Author(s) -
Busquets Sı́lvia,
Sanchı́s Daniel,
Alvarez Belén,
Ricquier Daniel,
López-Soriano Francisco J,
Argilés Josep M
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01485-9
Subject(s) - ucp3 , uncoupling protein , skeletal muscle , thermogenesis , endocrinology , medicine , brown adipose tissue , tumor necrosis factor alpha , cytokine , biology , adipose tissue
Since the discovery of the new members of the UCP (uncoupling protein) family, UCP2 and UCP3, very few studies have dealt with the regulation of their expression. Bearing this in mind, administration of a single intravenous injection of TNF‐α (100 μg/kg body weight) to rats resulted in a significant increase in UCP2 (242%) and UCP3 (113%) gene expression in skeletal muscle. The results suggest a possible role for UCP2 and UCP3 in the increase of energy expenditure associated with cytokine treatment.