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The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae
Author(s) -
Foury Françoise,
Roganti Tiziana,
Lecrenier Nicolas,
Purnelle Bénédicte
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01467-7
Subject(s) - genetics , mitochondrial dna , biology , genome , orfs , saccharomyces cerevisiae , sequence (biology) , intron , whole genome sequencing , complete sequence , computational biology , gene , open reading frame , peptide sequence
The currently available yeast mitochondrial DNA (mtDNA) sequence is incomplete, contains many errors and is derived from several polymorphic strains. Here, we report that the mtDNA sequence of the strain used for nuclear genome sequencing assembles into a circular map of 85 779 bp which includes 10 kb of new sequence. We give a list of seven small hypothetical open reading frames (ORFs). Hot spots of point mutations are found in exons near the insertion sites of optional mobile group I intron‐related sequences. Our data suggest that shuffling of mobile elements plays an important role in the remodelling of the yeast mitochondrial genome.