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Product activation of human erythrocyte AMP deaminase
Author(s) -
Mosharov E.V,
Vitvitsky V.M,
Ataullakhanov F.I
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01429-x
Subject(s) - deamination , amp deaminase , chemistry , biochemistry , enzyme , phosphate , adenosine deaminase , microbiology and biotechnology , biology
IMP was found to activate AMP deaminase in crude glucose‐depleted human erythrocyte lysates. Activation of the enzyme by IMP is due to prevention of the inhibitory effect of inorganic phosphate. At 1 mM AMP and 2–3 mM phosphate the addition of 2–5 mM IMP accelerates the AMP deamination two to three times.