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Neuronal expression of fractalkine in the presence and absence of inflammation
Author(s) -
Schwaeble Wilhelm J,
Stover Cordula M,
Schall Thomas J,
Dairaghi Daniel J,
Trinder Peter K.E,
Linington Christopher,
Iglesias Antonio,
Schubart Anna,
Lynch Nicholas J,
Weihe Eberhard,
Schäfer Martin K.-H
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01384-2
Subject(s) - chemokine , transmembrane protein , inflammation , cx3cl1 , extracellular , messenger rna , microbiology and biotechnology , chemistry , biology , immunology , gene , biochemistry , chemokine receptor , receptor
Fractalkine is the only as yet known member of a novel class of chemokines. Besides its novel Cys‐X‐X‐X‐Cys motif, fractalkine exhibits features which have not been described for any other member of the chemokine family, including its unusual size (397 amino acids human, 395 mouse) and the possession of a transmembrane anchor, from which a soluble form may be released by extracellular cleavage. This report demonstrates the abundant mRNA and fractalkine protein expression in neuronal cells. The neuronal expression of fractalkine mRNA is unaffected by experimentally induced inflammation of central nervous tissue.