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Tyrosine kinase activity is associated with CD44 in human neutrophils
Author(s) -
Skubitz Keith M,
Campbell Kenneth D,
Skubitz Amy P.N
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01347-7
Subject(s) - lyn , proto oncogene tyrosine protein kinase src , tyrosine kinase , receptor tyrosine kinase , signal transduction , tyrosine protein kinase csk , microbiology and biotechnology , chemistry , biology , sh2 domain
CD44 appears to be involved in signal transduction, however, the mechanism of this function is unclear. Protein kinase activity was detected in neutrophils associated with CD44. Most of the protein kinase activity associated with these antigens was tyrosine kinase activity. Src family kinases lyn and hck were found to account for much of the associated tyrosine kinase activity. The data suggest that associated tyrosine kinase activity may play a role in signal transduction from CD44 in neutrophils to regulate other cell functions.