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Immediate early response of the p62 gene encoding a non‐proteasomal multiubiquitin chain binding protein
Author(s) -
Lee Young Han,
Ko Jesang,
Joung Insil,
Kim Jung-Hye,
Shin Jaekyoon
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)01323-4
Subject(s) - gene , chain (unit) , chemistry , encoding (memory) , microbiology and biotechnology , genetics , biochemistry , biology , neuroscience , physics , astronomy
p62 is a cytoplasmic ubiquitin chain binding protein. Upon a variety of extracellular signals, both transcript and protein levels of p62 were rapidly increased. These signals include phorbol 12‐myristate 13‐acetate (PMA) and calcium ionomycin for peripheral blood mononuclear cells, serum or PDGF for serum‐starved NIH3T3 cells, IL‐3 for the G1 arrested pre‐B cell line Ba/F3, and PMA for a human promyelocyte line U937. The elevation of p62 transcript level is due to temporal stabilization of mRNA and rapid activation of the p62 gene. Cycloheximide‐induced enhanced transcription suggests the immediate early response of the p62 gene. The rapid induction of p62 indicates the presence of a novel ubiquitination‐mediated regulatory mechanism during cell proliferation and differentiation.